Structural biology of cellular signaling

Our goal is to study how proteins and RNAs involved in cellular signaling are able to encode cell signals at a physical level and “compute” this information to provide an appropriate output.

Structure of the Rac1 GEF Prex1

We use cryo-EM and other biophysical techniques to study several molecules involved in cellular signaling, including the small GTPases Rho and their regulators, and long non-coding RNAs.

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